Most models of RA have similar patterns to those that occur in human disease, although they present some differences such as: 1) faster progression of the condition than in humans, characterized by an acute inflammatory response and 2) rodents have a tendency to marked resorption and bone formation (especially periosteum / endosteum) in response to inflammation of the joints.
In general, the use of animal models of RA has contributed greatly to the knowledge of important processes and mediators in the generation of inflammation, cartilage destruction and bone resorption Flekosteel,
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